Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. doi: 10.1016/j.bmcl.2010.01.114. Epub 2010 Jan 25.

Abstract

From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.

MeSH terms

  • CDC2 Protein Kinase / antagonists & inhibitors*
  • Cyclin-Dependent Kinase 2 / antagonists & inhibitors*
  • Drug Design
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors*
  • Glycogen Synthase Kinase 3 beta
  • Models, Molecular
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology*
  • Substrate Specificity

Substances

  • Protein Kinase Inhibitors
  • Glycogen Synthase Kinase 3 beta
  • CDC2 Protein Kinase
  • Cyclin-Dependent Kinase 2
  • Glycogen Synthase Kinase 3