Abstract
From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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CDC2 Protein Kinase / antagonists & inhibitors*
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Cyclin-Dependent Kinase 2 / antagonists & inhibitors*
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Drug Design
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Glycogen Synthase Kinase 3 / antagonists & inhibitors*
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Glycogen Synthase Kinase 3 beta
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Models, Molecular
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacology*
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Substrate Specificity
Substances
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Protein Kinase Inhibitors
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Glycogen Synthase Kinase 3 beta
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CDC2 Protein Kinase
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Cyclin-Dependent Kinase 2
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Glycogen Synthase Kinase 3